Functional Safety compliance has taken center stage in the automotive industry with rigorous, semiconductor-level processes and failure targets embodied on the ISO 26262 standard. Certifying such compliance to the relevant ASIL tier, particularly in the face of growing design complexity and closer assessment scrutiny, calls for new paradigms and thinking. Traditionally, practitioners were able to rely on legacy architectures and use-models combined with targeted verification for selected logic units using customer-specific methodologies. For the highest safety levels, logic or component replication offered a way out. The enhanced scrutiny for level3+ autonomous driving made possible by new IC architectures makes the former approach unattractive while the economics of the hardware costs make replication unviable. From a standards perspective, the preference for Fault simulation is made clear but safety engineers face a few obstacles to widespread adoption of Fault sims as the de-facto methodology. In this session, we will review some of the hurdles holding the industry back from conducting exhaustive fault campaigns and some innovative approaches to solving them. Also included is a review of acceleration strategies and best practices to enable them.