How CDC cause the respin?

Since the CDC is 2nd majore cause of respin, how it will cause the respin and how to avoid the cause

In reply to K V:

CDC causes problems such as metastability are created by the analog component of digital logic. There problems are hard to catch with digital functional simulation or static timing analysis. See https://learn.sw.siemens.com/library/functional-verification/VyX0-NUrf/learning-paths/questa-clock-domain-crossing-cdc/V1J9D-OLS