Alignment question - not specific to SV

Hi,

If I have a 38-bit address and I want to make it unaligned to 256B boundary, which bits should I make non-zero? Can it be any of the lower [7:0] !=0 or does it have to be [7:6]?

If all are wrong, please help understand.

Any bit non-zero in [7:0] would make it unaligned to 256B. I hope you have a byte-addressable design.